Russell S. Thomas, Ph.D.
Director, Center for Computational Toxicology and Exposure, Environmental Protection Agency
Mark Cronin, Ph.D.
Professor, Cheminformatics Research Group, Liverpool John Moores University
Special Guest Speaker
Elizabeth Mannshardt PhD
Statistician, Office of Air Quality Planning and Standards, US Environmental Protection Agency
Adjunct Associate Professor at North Carolina State University
The meeting will feature:
- Platform, poster, and networking sessions
- Panel discussions
- Training sessions on specific tools
Training Sessions June 11
Organizers will offer three potential training sessions the morning of June 11. Exact details and length to be announced; the sessions will last until about 12:00 PM. When you register, please indicate your interest in attending any of the sessions so organizers may plan for the number of potential attendees. Lack of interest may result in cancellation of a session. The trainings are offered to conference registrants at no extra cost.
SESSION 1: Practical applications of New Approach Methodologies (NAM) in chemical safety assessment: applying US EPA tools/approaches in practice
This hands-on training course will provide attendees with a working knowledge on how to effectively access and exploit the many different data streams available in the EPA’s CompTox Chemicals Dashboard to support different regulatory purposes. The training is targeted towards regulatory scientists, students, and researchers. The course will include an overview of the dashboard itself and its main capabilities, before providing more in-depth training through case studies for each data stream (e.g. interpretation of ToxCast high-throughput screening data, use of read-across, generating QSAR predictions). A final case study will showcase how to integrate all the different data streams together for chemical safety assessment purposes. A laptop with access to the internet is required.
SESSION 2: AOP Hands-on Training: Building the Foundation for Predictive Toxicology
An adverse outcome pathway (AOP) is a structured representation of biological events leading from an initial molecular initiating event to an adverse effect. As the availability of mechanistic toxicological data and interest in moving away from apical in vivo endpoints has grown, efforts to describe and use AOPs has grown significantly. Eight years after the launch of the Organization for Economic Cooperation and Development’s AOP Programme, there are hundreds of AOPs being developed and several under review and endorsement. Outside the official OECD program, the AOP is being used as a backbone for organizing evidence and bolstering decision-making in toxicology and beyond.
The sponsors of this training invite you to deepen your understanding of the AOP framework. The training will present a conceptual overview followed by presentations demonstrating the principles of development and examples of applications of AOPs via case studies representing different contexts of use. Tools for AOP development and recording will be demonstrated, giving participants a chance to try out AOP development on their own laptops. A focus of the workshop will be on integration of various streams of toxicological evidence to support regulatory decision-making and the development of in vitro and in silico tools supported by AOP information.
SESSION 3: Hands-on Training on Scientific Tools and Methods Developed through the Long Range Research Initiatives of CEFIC, ACC and JCIA
The LRI programs of CEFIC, JCIA and ACC have supported researchers in the development of many different types of tools and methods to improve scientific approaches for evaluating fate, transport, exposure, bioactivity, hazard and potential risks. This session will feature 4-5 stations each providing a one-half hour hands on participation/demonstration of a specific tool/method. Participants will then rotate to the next station featuring one-half hour training on another tool/model, and so on throughout the session. A number of the tools and models to be featured in this training session are described (and can be previewed) online at the CEFIC LRI Tool Box and at ACC LRI Scientific Tools and Methods.