Presenter: Chihae Yang, Altamira, LLC and Molecular Networks
Date/Time: July 24, 2014 at 11:00 US ET
Abstract: In development of alternatives to animal testing, the Threshold of Toxicological Concern (TTC) approach can serve as one of the practical safety assessment tools for chemicals for which no in vivo testing results are available. It is a risk assessment paradigm that establishes a human exposure threshold value for chemicals, below which there is a low probability of an appreciable risk to human health.
One of the goals of the COSMOS Project is the evaluation and extension of the current TTC approach for the safety assessment of cosmetics-related chemicals, contributing to alternative safety assessment methods urgently needed to address the repeated toxicity testing of cosmetics. Fundamental to this has been the compilation of a new oral repeated-dose toxicity database, oRepeatTox DB, as a resource to construct the new COSMOS non-cancer TTC database of No Observable Adverse Effect Levels (NOAELs). The TTC database quality was reviewed by external experts of an ILSI-EU Expert Group. Among the strategies to address the application of TTC values derived from oral data to use cases relevant to cosmetics, a tiered decision tree workflow has been elaborated for the assessment of the chemicals’ bioavailability.
In the webinar, a short general introduction to the TTC concept will be given and the COSMOS approach to create the new, cosmetics-relevant TTC dataset will be presented along with the oral-to-dermal extrapolation approach.
Please contact the ASCCT Secretary, Kristie Sullivan, for more access information.
Acknowledgements: The COSMOS Project is funded by the European Community’s Seventh Framework Programme (FP7/2007-2013) under grant agreement number 266835 and the European Cosmetics Association Cosmetics Europe. More information on the COSMOS Project is available from http://www.cosmostox.eu.
9th World Congress on Alternatives and Animal Use in the Life Sciences
Humane Science in the 21st Century
Aug. 24-28, 2014
Prague, Czech Republic
Satellite Session: “AOPs 101”: The how and why of development and use
Sunday, August 24, 2014, 10:00—12:00
Hotel Jurys Inn, Prague
Adverse Outcome Pathways: From Research to Regulation
September 3-5, 2014
William H. Natcher Conference Center
National Institutes of Health
Bethesda, Maryland, USA
Registration is FREE and open until August 15
The traditional model of toxicology testing, which involves treating animals with test substances and observing outcomes, may not be sufficient to serve future scientific and regulatory needs. The science of toxicology is turning towards a new model based on a better understanding of toxicity mechanisms, which will enable prediction of toxic effects in humans.
A key element of a mechanistic understanding of a specific toxicity is the construction of an adverse outcome pathway for that toxicity. An adverse outcome pathway is a conceptual framework constructed from existing knowledge that relates exposure of a type of toxic substance to subsequent molecular and cellular changes that result in illness or injury to an individual or population.
Effective communication between researchers and regulators is a critical determinant of whether new methods or approaches are efficiently translated from the scientific bench to regulatory decision-making practice. This workshop will explore how scientific progress in adverse outcome pathway concepts can improve regulatory assessment of chemical toxicity.
The workshop will feature extensive time devoted to breakout sessions and discussions and a hands-on training session.
The workshop will run from 8:30 a.m. to approximately 5:30 p.m. Eastern Daylight Time (EDT) on September 3 and 4 and from 9:00 a.m. to approximately 4:00 p.m. EDT on September 5. A poster session will be held on September 4 from 6:30-8:30 p.m. The plenary sessions will be web cast; breakout sessions and discussions will not. To register to attend in person or view the web cast, to view an updated workshop program, to see instructions for poster abstract submission or information on travel support for young investigators, for travel information, or for any other information visit the workshop website here.
Where Chemistry and Biology Meet: AOPs as a Framework for Advancing Toxicology
3rd Annual ASCCT Meeting
November 12, 2014
Abstract submission deadline Sept. 26
The 3rd annual ASCCT meeting will feature Dr. Robert Kavlock, Deputy Assistant Administrator for Science, Office of Research and Development, US EPA, and will include a panel discussion, talks chosen from submitted abstracts, a poster session, and a reception. More details and registration and abstract submission information can be found here.
- Medical Device Irritation Testing: An In Vitro Alternative | Kelly Coleman, Medtronic Biomaterials Dept
- Developing Confidence in 21st-Century Risk Assessments | Craig Rowlands, Dow Chemical Company
- COSMOS DB: A New Database of Toxicological Information to Support Knowledge Discovery | Mark Cronin, Liverpool John Moores University and COSMOS project coordinator
- High Content Imaging Approaches in Neurotoxicology and Neurodegeneration Research | Marcel Leist, University of Konstanz and CAAT Europe
- EURL ECVAM's Approach to Validation of Alternative Methods | Valerie Zhuang, EURL ECVAM
- Using the AOP Framework to Develop HTS Assays for Thyroid-Disrupting Chemicals | Katie Paul, US EPA
- The Role of Non-Animal Methods in the Regulation of Nanomaterials in the United States | Erik Janus, Steptoe and Johnson LLP (Recording not available)
- Human Induced Pluripotent Stem Cell-derived Model Systems | Maureen Bunger, Cellular Dynamics
- Incorporating New Technologies into Toxicity Testing and Risk Assessment | Russell Thomas, The Hamner Institutes for Health Science
- The Virtual Embryo | Nicole Kleinstreuer, US EPA
- Tox21 Program Update | Raymond Tice, National Toxicology Program, NIH
- Evidence-Based Toxicology (EBT) for the 21st Century | Martin Stephens, Johns Hopkins University
- Effectopedia: The Online Encyclopedia of Adverse Effect Pathways | Gilman Veith and Hristo Aladjov, International QSAR Foundation
- MetaPath: A Metabolism Pathway Database | Patricia Schmeider, US EPA
Second Annual Scientific Meeting of the American Society for Cellular and Computational Toxicology: The Future Is Here: Practical Applications of Emerging Scientific Tools
Human Organs on Chips as Replacements for Animal Testing, the keynote address given by Donald E. Ingber, M.D., Ph.D., of the Wyss Institute at Harvard, kicked off the meeting which featured a dozen lectures and poster presentations on making toxicology a more human-relevant science. Other topics included methods to replace live animals in eye irritation tests and computer-based virtual embryos that show how chemical exposures might affect developing embryos. View Program. ASCCT members, click here to view select presentations.
First Annual Scientific and Business Meeting of the ASCCT
The first annual ASCCT meeting focused on advances in the fields of in vitro and computational toxicology. Dr. Melvin Andersen, associate director of The Institute for Chemical Safety Sciences at The Hamner Institutes for Health Sciences and ASCCT board member, gave a plenary lecture on Computational Cellular Pathway Modeling: Combining Key In Vitro and In Silico Tools to Enhance Modern Safety Assessment. Dr. Suzanne Fitzpatrick, senior advisor for toxicology at the U.S. Food and Drug Administration gave a plenary lecture on an Overview of the FDA-DARPA-NIH Collaboration on Human/Organ on a Chip.
Institute for In Vitro Sciences Practical Methods for In Vitro Toxicology Workshop
Attendees gained hands-on laboratory experience and instruction in the practical application of the lectured topics. Topics for the three and a half day course included: (i) international regulatory acceptance status of in vitro assays, (ii) predicting organ specific toxicity (e.g., ocular, dermal and hepatic), (iii) using cell and organ culture models with histological, biochemical, and molecular endpointsm, and (iv) data interpretation.
2010 In Vitro Alternatives Forum
Thank you for contributing to a successful forum. Read the post-meeting report.
8th World Congress for Alternatives and Animal Use
Thank you for helping to make the ASCCT/ESTIV luncheon session a success. A manuscript outlining the discussions that took place during the session has been published. You can view the entire proceedings here.