In Vitro Medical Device Testing Symposium
Dec. 10-11, 2013
Johns Hopkins, Mt. Washington Conference Center
This symposium, hosted by the Johns Hopkins Center for Alternatives to Animal Testing (CAAT), will examine how the National Academy of Sciences, Toxicity Testing in the 21st Century can be applied to Medical Devices. The program will examine current requirements and testing approaches, followed by an examination of in vitro assays useful in medical device testing.
Dec. 19, 2013, 10:30 - 11:30 a.m. EST
Presenter: Prof. Marcel Leist, University of Konstanz, CAAT-Europe
Please join your fellow ASCCT members for a webinar exploring high content imaging approaches for toxicology. On Oct. 24 CAAT Europe and several other sponsors held a joint information day to discuss HCI systems, which provide quantitative data from cellular assays involving automated microscopy and image analysis. These multi-parametric data sets refer to multiple endpoints and can be obtained from large numbers of cells with higher-throughput, in an observer-independent standardized way. This presentation will give a brief summary of the proceedings of the information day, which discussed the implementation of the HCI approach in regulatory safety sciences, and then focus on the possibilities of the HCI technology for examination of damage mechanisms and toxic effects of neurotoxic chemicals and in neurodegeneration research. Members, click here to register. Nonmembers, contact the Secretary for access information.
Jan. 13-16, 2014
Attend highly informative lectures given by experts in the field. Gain hands-on laboratory experience and instruction in the practical application of the lecture topics.
Jan. 16-17, 2014
Chapel Hill, N.C.
The National Research Council (NRC) report “Toxicity Testing in the 21st Century: A Vision and a Strategy” outlined a new paradigm for assessing toxicity. The vision was to move away from animal testing to high-throughput and in vitro assays that assess how chemical compounds perturb cellular functions. Central to this strategy is the ability to predict adverse outcomes of a traditional in vivo animal testing strategy using in vitro data and in silico models. “FutureTox II” is a Contemporary Concepts in Toxicology (CCT) conference of the Society of Toxicology (SOT) that will focus on the central question: In what ways can in vitro/in silico methodologies be seen as superior to in vivo methods such that the latter would not be needed to confirm findings? Abstract Submission Deadline: Dec. 15, 2013
Society of Toxicology
March 24-27, 2014
Late-breaking abstracts accepted until Jan. 6, 2014.
May 12-14, 2014
Developmental neurotoxicity from chemical exposures is a growing concern. The developing human nervous system is susceptible to pharmaceuticals and environmental contaminants, and exposure during development is known to cause lasting neurological deficits. This conference will bring together diverse stakeholders from around the globe, including research scientists, regulators, industry representatives, academics, and pediatricians. Abstract Submission Deadline: Dec. 31, 2013
June 10-13, 2014
Egmond aan Zee, The Netherlands
Abstract Submission Deadline: Feb. 1, 2014
Humane Science in the 21st Century
Aug. 24-28, 2014
Prague, Czech Republic
Abstract Submission Deadline: April 1, 2014
Webinar on EURL ECVAM's Approach to the Validation of Alternative Methods
Dr. Valerie Zuang, coordinator of the EURL ECVAM validation workflow, presented EURL ECVAM's validation workflow, including information on the regulators' network (PARERE), stakeholder involvement, and its scientific peer review process (ESAC). Dr. Zuang also reviewed EURL ECVAM recommendations and strategy documents, discussed the test methods which are currently in the validation pipeline, and gave an overview of international activities at the OECD and with ICATM. EURL ECVAM is the European Union Reference Laboratory for alternatives to animal testing and is housed within the Joint Research Centre, located in Ispra, Italy. Since 1991, this laboratory has been a worldwide leader in contributing to the development and validation of methods which reduce, refine or replace the use of animals for safety testing and efficacy/potency testing of chemicals, biologicals, and vaccines. Click here to access the webinar.
Webinar on Using the Adverse Outcome Pathway Framework as a Guide for the Development of High-Throughput Screening Assays for Thyroid-Disrupting Chemicals
Disruption of thyroid hormones (THs) adversely affects neurodevelopment in both rodent models and humans. Therefore it is critical to determine the potential thyroid-disrupting activity of environmentally relevant chemicals, but the complexity of thyroid hormone regulation necessitates screening assays for multiple molecular initiating events that are not currently associated with any screening assays. Katie B. Paul, Ph.D., Oak Ridge Institute for Science and Education Postdoctoral Research Fellow at the U.S. Environmental Protection Agency, discussed the system of adverse outcome pathways for thyroid disruption, the development of a high-throughput screening assay for the detection of thyroperoxidase inhibitors, and future thyroid-disruptor screening challenges and potential approaches. Click here to access the webinar.
Webinar on Human Induced Pluripotent Stem Cell-derived Model System
Induced pluripotent stem cells (iPSC) can be differentiated to almost any cell type, and have the potential to help bridge the gap between in chemico or receptor-based in vitro assays and organ toxicities in the adverse outcome pathway framework. Dr. Maureen Bunger from Cellular Dynamics International presented the process of reprogramming adult cells to create iPSCs and subsequent directed differentiation and purification of multiple cell lineages, and provided examples of their utility in vitro toxicity testing. Click here to access the webinar.
The first annual ASCCT meeting focused on advances in the fields of in vitro and computational toxicology. Dr. Melvin Andersen, associate director of The Institute for Chemical Safety Sciences at The Hamner Institutes for Health Sciences and ASCCT board member, gave a plenary lecture on Computational Cellular Pathway Modeling: Combining Key In Vitro and In Silico Tools to Enhance Modern Safety Assessment. Dr. Suzanne Fitzpatrick, senior advisor for toxicology at the U.S. Food and Drug Administration gave a plenary lecture on an Overview of the FDA-DARPA-NIH Collaboration on Human/Organ on a Chip.
Webinar on New Technologies in Risk Assessment
Dr. Russell Thomas, The Hamner Institutes for Health Sciences, presented a webinar on Incorporating New Technologies into Toxicity Testing and Risk Assessment: Moving from 21st Century Vision to a Data-Driven Framework. Click here for a recording of the webinar.
Webinar on the EPA Virtual Embryo Project
Nicole C. Kleinstreuer presents her work on the Virtual Embryo Project, and effort to create biologically based computational toxicology models of the developing embryo. Click here to view a recording of the webinar.
Webinar Update on the Tox21 Program
Dr. Raymond Tice of the National Institute for Environmental Health Sciences presents an update of the Tox21 program, a collaborative effort between three government agencies to use hundreds of cell-based assays to predict human health effects. Click here for a recording of the webinar.
Webinar on Evidence-Based Toxicology
Dr. Martin Stephens of the Center for Alternatives to Animal Testing at Johns Hopkins University presents how evidence-based toxicology can help address the challenge of critically assessing the new methods themselves as well as the data generated by emerging and traditional methods. Click here for a recording of the webinar.
Institute for In Vitro Sciences Practical Methods for In Vitro Toxicology Workshop
Attendees gained hands-on laboratory experience and instruction in the practical application of the lectured topics. Topics for the three and a half day course included: (i) international regulatory acceptance status of in vitro assays, (ii) predicting organ specific toxicity (e.g., ocular, dermal and hepatic), (iii) using cell and organ culture models with histological, biochemical, and molecular endpointsm, and (iv) data interpretation.
Webinar on Effectopedia
Dr. Gilman Veith and Dr. Hristo Aladjov of the International QSAR Foundation presented a webinar describing Effectopedia, an online encyclopedia of adverse effects pathways. Click here for a recording of the webinar.
2010 In Vitro Alternatives Forum
Thank you for contributing to a successful forum. Read the post-meeting report.
Webinar on MetaPath
Dr. Patricia Schmieder of the EPA's National Health and Environmental Effects Research Laboratory gave the first ASCCT member webinar describing MetaPath, a Metabolism Pathway Database and computational tool developed by the EPA. Click here for a recording of the webinar.
8th World Congress for Alternatives and Animal Use
Thank you for helping to make the ASCCT/ESTIV luncheon session a success. A manuscript outlining the discussions that took place during the session has been published. You can view the entire proceedings here.