Meetings and Events

Upcoming Events



WEBINAR: Human Primary Cell-Based In Vitro Systems for Translational Drug Safety and Mechanisms of Toxicity
May 31, 2016
2:00-3:00 PM US ET

Register here.

Ellen L. Berg
General Manager
BioSeek, a division of DiscoveRx

Human cell-based in vitro assays that are physiologically relevant and also amenable to large scale chemical testing are advancing our understanding of toxicity mechanisms.

BioMAP® Systems are standardized panels of human primary cell-based and co-culture assays that have been developed to model human tissue and disease states. A large reference database of proteomic profiles, comprised of changes in protein biomarker levels, has been developed using these systems for a set of drugs and chemicals with known toxicities or adverse drug reactions (ADRs). This reference dataset includes profiles of approved and failed drugs, experimental chemicals, and compounds tested as part of the United States Environmental Protection Agency¹s ToxCastTM program.

Examples where novel associations between assay biomarkers, target mechanisms, and human ADRs have been identified include: (1) skin side effects induced by MEK kinase inhibitors (e.g. trametinib, pimasertib and selumetinib), p38 MAPK inhibitors, and the IL-1 receptor antagonist, anakinra; (2) thrombosis-related side effects, associated with sirolimus, selective estrogen receptor modulators and certain second generation anti-psychotic drugs; and (3) skin irritation induced by retinoids and chemical vesicants.
By connecting mechanisms to ADRs, this data-driven approach is improving our knowledge of toxicity mechanisms underlying adverse drug reactions and can also contribute to the construction of adverse outcome pathway (AOP) frameworks.

After registering, you will receive a confirmation email containing information about joining the webinar.


WEBINAR: Rapid 3D Bioprinting: an Enabling Technology for Creating Functional Tissue Models
June 17, 2016
2:00-3:00 PM US ET

Register here.


Shaochen Chen, Ph.D.
Professor of NanoEngineering and Bioengineering Departments
Co-Director, Biomaterials & Tissue Engineering Center
University of California, San Diego


The goal of our laboratory is to develop micro- and nano-scale bioprinting and 3D printing techniques to create 3D designer scaffolds for tissue engineering and regenerative medicine. In this talk, I will present my laboratory’s recent research efforts in rapid continuous projection 3D bioprinting to create 3D scaffolds using a variety of biomaterials. These 3D biomaterials are functionalized with precise control of micro-architecture, mechanical (e.g. stiffness and Poisson’s ratio), chemical, and biological properties. Design, fabrication, and experimental results will be discussed. Such functional biomaterials allow us to investigate cell-microenvironment interactions at nano- and micro-scales in response to integrated physical and chemical stimuli. From these fundamental studies we can create in vitro tissue models for precision tissue engineering and regenerative medicine.

After registering, you will receive a confirmation email containing information about joining the webinar.


17th International Conference on QSAR in Environmental and Health Sciences

June 13-17, 2016
Miami Beach, FL

Early Bird reg: March 1, 2016

Since 1983, this Conference has been an important international gathering in the field of Environmental and Health Sciences, bringing together scientists developing and using (Q)SARs.

This meeting will bring together both developers and users of (Q)SAR methodologies from around the world, and in addition to a comprehensive program offer opportunities for career development with many courses and an on-going “Jobs Fair” to connect employers with potential employees.

The ASCCT is providing travel awards of $850 each for three students to travel to QSAR2016. Congratulations to the three winners:

Quantitative relationship between skin sensitization and skin extract membrane penetration
Mare Oja, Institute of Chemistry, University of Tartu, Tartu, Estonia

Development of a fragment-based in silico method for the prediction of chemical reactivity
David J. Ebbrell, School of Pharmacy and Bimolecular Sciences, Liverpool John Moores University, Liverpool, United Kingdom

The importance of data curation on QSAR Modeling: EPISuite data as a case study
Kamel Mansouri, ORISE Postdoctoral Fellow, US EPA, Research Triangle Park, NC, US

Agenda tracks include:

  • Track 1: Experience from a regulatory accepted use of (Q)SAR models: The ICH M7 guidance for pharmaceutical impurities
  • Track 2: Using read-across and (Q)SAR models to support industrial applications (including REACH)
  • Track 3: Best practices in the development of fit-for-purpose (Q)SAR models
  • Track 4: (Q)SAR Methodologies
  • Track 5: Using (Q)SARs as part of hazard and risk assessment

Poster session, panel discussions, and a debate will also be held. Several continuing education sessions will be offered, including one on Describing Adverse Outcome Pathways.

Visit the conference web site for more information.


European Congress on Alternatives to Animal Testing 

August 24-27, 2016
Linz, Austria

Abstract submission deadline: May 31, 2016

Tentative Topic List:

  • 25th Anniversary of 3R Congresses on Alternatives in Linz: MEGAT & EUSAAT
  • Global Cooperation on Implementing the 3Rs
  • Ethical and Legal Issues 
  • Implementing EU Dir 63/2010
  • Novel Approaches in Efficacy and Safety Testing – Human 3D Models & Multi-Organ-Chips
  • Stem Cells & Reproductive Toxicity (including mEST & hEST)
  • Refinement & Welfare: Culture of Care, Best Practice Approaches, Avoidance of Severe Suffering
  • Replacement: New Approaches
  • Predictive Toxicology: QSAR & Read Across
  • Specific Endpoints of Toxicity I: oral & repeated-dose Toxicity, Inhalation Toxicity
  • Specific Endpoints of Toxicity II: Sensitization, Nano-toxicology & Bio-barriers
  • Efficacy and Safety Testing of Drugs, Biologicals and Vaccines
  • Disease Models in vitro versus in vivo
  • Advanced GMO models – CRISPR/cas in vitro versus in vivo 
  • 3Rs in Education and Academia
  •  "Young Scientists” session
  • Free communications


5th Annual Meeting of the ASCCT

September 29-30, 2016
Research Triangle Park, NC


  • Two themed sessions: Read Across and Pluripotent Stem Cells (PSCs)
  • Panel discussion on PSCs
  • Free communications chosen from submitted abstracts
  • Poster session & Mentoring activity
  • Social reception and awards ceremony

Click here for abstract submission, registration, and program details. Abstract submission deadline is July 22.


International Congress of Toxicology

October 2-6, 2016
Merida, Mexico

Abstract Submission deadline: April 30, 2016

European Society for Toxicology In Vitro 

October 17-20, 2016
Juan-les-Pins, France

Abstract submission deadline: May 15, 2016


  • Emerging technologies for in vitro tissue/organ toxicity testing
  • Extrapolation dose / modelling
  • Systemic toxicity
  • Endocrine disruption
  • Biopharmaceuticals
  • Regulatory updates (validation, ITS, regulatory application)
  • Mixtures

Past Educational Member Webinars

ASCCT members, click here to access recordings of past webinars listed below. Contact the Secretary for more information or to suggest a topic for a future webinar.

  • Integrating in silico predictions with PBPK modeling | Michael Lawless, SimulationsPlus, Inc.
  • The GARD assay for skin and respiratory sensitization | Andy Forreryd, Lund University
  • COSMOS: Automated in silico tools for in vitro to in vivo extrapolation| Alicia Paini, European Commission Joint Research Centre
  • Threshold of Toxicological Concern – an approach for safety assessment and its applicability to cosmetics-related chemicals | Chihae Yang, Altamira, LLC and Molecular Networks
  • Medical Device Irritation Testing: An In Vitro Alternative | Kelly Coleman, Medtronic Biomaterials Dept
  • Developing Confidence in 21st-Century Risk Assessments | Craig Rowlands, Dow Chemical Company
  • COSMOS DB: A New Database of Toxicological Information to Support Knowledge Discovery | Mark Cronin, Liverpool John Moores University and COSMOS project coordinator
  • High Content Imaging Approaches in Neurotoxicology and Neurodegeneration Research | Marcel Leist, University of Konstanz and CAAT Europe
  • EURL ECVAM's Approach to Validation of Alternative Methods | Valerie Zhuang, EURL ECVAM
  • Using the AOP Framework to Develop HTS Assays for Thyroid-Disrupting Chemicals | Katie Paul, US EPA
  • The Role of Non-Animal Methods in the Regulation of Nanomaterials in the United States | Erik Janus, Steptoe and Johnson LLP (Recording not available)
  • Human Induced Pluripotent Stem Cell-derived Model Systems | Maureen Bunger, Cellular Dynamics
  • Incorporating New Technologies into Toxicity Testing and Risk Assessment | Russell Thomas, The Hamner Institutes for Health Science
  • The Virtual Embryo | Nicole Kleinstreuer, US EPA
  • Tox21 Program Update | Raymond Tice, National Toxicology Program, NIH
  • Evidence-Based Toxicology (EBT) for the 21st Century | Martin Stephens, Johns Hopkins University
  • Effectopedia: The Online Encyclopedia of Adverse Effect Pathways | Gilman Veith and Hristo Aladjov, International QSAR Foundation
  • MetaPath: A Metabolism Pathway Database | Patricia Schmeider, US EPA

Past Events

Fourth Annual Scientific Meeting of the American Society for Cellular and Computational Toxicology: Promises and Challenges of a More Flexible Approach to Toxicology Testing

The fourth annual ASCCT meeting explored new approaches to toxicology testing with plenary lectures given by Warren Casey, Director of NICEATM and Craig Rowlands from the Dow Chemical Company. The meeting featured a diverse poster session, a panel discussion on the assessment and application of IATA, and ten oral presentations chosen from a very competitive field of abstracts. Members elected two new members to the Board of Directors: Gertrude-Emilia Costin and Shaun McCullough. View Program.  ASCCT members, click here to view all presentations.
Third Annual Scientific Meeting of the American Society for Cellular and Computational Toxicology: Where Chemistry and Biology Meet: AOPs as a Framework for Advancing Toxicology

Dr. Robert Kavlock of the US Environmental Protection Agency opened the meeting with a discussion on the development of the Adverse Outcome Pathways concept, in which AOPs offer a biological context to facilitate the development of Integrated Approaches to Testing and Assessment (IATA) for regulatory decision-making. Drs. Jennie Larkin and Ajay Pillai from NIH discussed BD2K and LINCS, two community-building programs. Other presenters explored the development of different tools used to test toxicity. A poster session and reception concluded the meeting. View Program. ASCCT members, click here to view all presentations.

Second Annual Scientific Meeting of the American Society for Cellular and Computational Toxicology: The Future Is Here: Practical Applications of Emerging Scientific Tools
Human Organs on Chips as Replacements for Animal Testing, the keynote address given by Donald E. Ingber, M.D., Ph.D., of the Wyss Institute at Harvard, kicked off the meeting which featured a dozen lectures and poster presentations on making toxicology a more human-relevant science. Other topics included methods to replace live animals in eye irritation tests and computer-based virtual embryos that show how chemical exposures might affect developing embryos. View Program.

First Annual Scientific and Business Meeting of the ASCCT
The first annual ASCCT meeting focused on advances in the fields of in vitro and computational toxicology. Dr. Melvin Andersen, associate director of The Institute for Chemical Safety Sciences at The Hamner Institutes for Health Sciences and ASCCT board member, gave a plenary lecture on Computational Cellular Pathway Modeling: Combining Key In Vitro and In Silico Tools to Enhance Modern Safety Assessment. Dr. Suzanne Fitzpatrick, senior advisor for toxicology at the U.S. Food and Drug Administration gave a plenary lecture on an Overview of the FDA-DARPA-NIH Collaboration on Human/Organ on a Chip. View Program.

Institute for In Vitro Sciences Practical Methods for In Vitro Toxicology Workshop
Attendees gained hands-on laboratory experience and instruction in the practical application of the lectured topics. Topics for the three and a half day course included: (i) international regulatory acceptance status of in vitro assays, (ii) predicting organ specific toxicity (e.g., ocular, dermal and hepatic), (iii) using cell and organ culture models with histological, biochemical, and molecular endpointsm, and (iv) data interpretation.

2010 In Vitro Alternatives Forum
Thank you for contributing to a successful forum. Read the post-meeting report.

8th World Congress for Alternatives and Animal Use
Thank you for helping to make the ASCCT/ESTIV luncheon session a success. A manuscript outlining the discussions that took place during the session has been published. You can view the entire proceedings here.